Mitochondrial proteomics as a selective tool for unraveling Parkinson’s disease pathogenesis

@article{Pienaar2010MitochondrialPA,
  title={Mitochondrial proteomics as a selective tool for unraveling Parkinson’s disease pathogenesis},
  author={Ilse S. Pienaar and David T Dexter and Pierre R. Burkhard},
  journal={Expert Review of Proteomics},
  year={2010},
  volume={7},
  pages={205 - 226}
}
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the large-scale loss of dopaminergic neurons in the substantia nigra and the formation of protein aggregates that accumulate in the cytoplasm of the remaining dopaminergic neurons. Most cases arise sporadically, while the precise cause remains obscure. This lack of understanding as to the etiology of PD continues to serve as a major barrier for delivering effective therapeutics. Mitochondria are potent integrators and… 
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References

SHOWING 1-10 OF 237 REFERENCES
Neuroproteomics as a promising tool in Parkinson’s disease research
TLDR
It is hoped that the application of neuroproteomics will lead towards a presymptomatic diagnosis of PD, and the identification of risk factors and new therapeutic targets at which pharmacological intervention can be aimed.
A proteomic approach in the study of an animal model of Parkinson's disease.
Applied proteomics: mitochondrial proteins and effect on function.
TLDR
For any proteomics approach prefractionation of complex protein mixtures is essential to facilitate the identification of low-abundance proteins because the dynamic range of protein abundance within cells has been estimated to be as high as 10(7).
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
TLDR
Removal of Drosophila PINK1 homologue function results in male sterility, apoptotic muscle degeneration, defects in mitochondrial morphology and increased sensitivity to multiple stresses including oxidative stress, which underscores the importance of mitochondrial dysfunction as a central mechanism of Parkinson's disease pathogenesis.
Mitochondrial dysfunction in Parkinson's disease.
TLDR
A novel model of PD is developed in which chronic, systemic infusion of rotenone, a complex-I inhibitor, selectively kills dopaminergic nerve terminals and causes retrograde degeneration of substantia nigra neurons over a period of months, which should enhance the understanding of neurodegeneration in PD.
...
...