Mitochondrial proteomic approaches for new potential diagnostic and prognostic biomarkers in cancer.

@article{Bottoni2012MitochondrialPA,
  title={Mitochondrial proteomic approaches for new potential diagnostic and prognostic biomarkers in cancer.},
  author={Patrizia Bottoni and Bruno Giardina and Alessandro Pontoglio and Salvatore Scar{\`a} and Roberto Scatena},
  journal={Advances in experimental medicine and biology},
  year={2012},
  volume={942},
  pages={423-40}
}
Mitochondrial dysfunction and mutations in mitochondrial DNA have been implicated in a wide variety of human diseases, including cancer. In recent years, considerable advances in genomic, proteomic and bioinformatic technologies have made it possible the analysis of mitochondrial proteome, leading to the identification of over 1,000 proteins which have been assigned unambiguously to mitochondria. Defining the mitochondrial proteome is a fundamental step for fully understanding the organelle… CONTINUE READING