Mitochondrial protein phosphorylation as a regulatory modality: implications for mitochondrial dysfunction in heart failure.

@article{ORourke2011MitochondrialPP,
  title={Mitochondrial protein phosphorylation as a regulatory modality: implications for mitochondrial dysfunction in heart failure.},
  author={Brian O'Rourke and Jennifer E. van Eyk and D. Brian Foster},
  journal={Congestive heart failure},
  year={2011},
  volume={17 6},
  pages={269-82}
}
Phosphorylation of mitochondrial proteins has been recognized for decades, and the regulation of pyruvate- and branched-chain α-ketoacid dehydrogenases by an atypical kinase/phosphatase cascade is well established. More recently, the development of new mass spectrometry-based technologies has led to the discovery of many novel phosphorylation sites on a variety of mitochondrial targets. The evidence suggests that the major classes of kinase and several phosphatases may be present at the… CONTINUE READING

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