Mitochondrial protein phosphatase 2A regulates cell death induced by simulated ischemia in kidney NRK-52E cells.

@article{Tsao2007MitochondrialPP,
  title={Mitochondrial protein phosphatase 2A regulates cell death induced by simulated ischemia in kidney NRK-52E cells.},
  author={Chun Chui Tsao and Alina Felicia Nica and Svitlana M Kurinna and Tilahun W Jiffar and Marc C. Mumby and Peter P Ruvolo},
  journal={Cell cycle},
  year={2007},
  volume={6 19},
  pages={2377-85}
}
Acute renal failure can occur after an ischemic injury and results in significant mortality. The stress-signaling pathways that are activated during renal ischemia are unknown. PP2A has emerged as an important regulator of cell death. To study the role of PP2A in ischemia-induced cell death, we used an in vitro model of simulated ischemia. In the present study, simulated ischemia in rat renal tubule epithelial NRK-52E cells (A) results in cell death that involves both necrosis and apoptosis, (B… CONTINUE READING

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