Mitochondrial protein-import machinery: correlating structure with function.

  title={Mitochondrial protein-import machinery: correlating structure with function.},
  author={M. J. Baker and Ann E Frazier and Jacqueline M. Gulbis and Michael T Ryan},
  journal={Trends in cell biology},
  volume={17 9},
Most mitochondrial proteins are synthesized in the cytosol, translocated into the organelle and directed along specific sorting pathways. Over the past 20 years, >30 proteins have been identified as having key roles in mitochondrial protein import. Recently, the elucidation of the structures of several import components has provided fresh insight into the import process. Here, we review the different pathways involved in sorting proteins into mitochondrial subcompartments. Along the way, we… CONTINUE READING

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