Mitochondrial protein import: from proteomics to functional mechanisms

  title={Mitochondrial protein import: from proteomics to functional mechanisms},
  author={Oliver Schmidt and Nikolaus Pfanner and Chris Meisinger},
  journal={Nature Reviews Molecular Cell Biology},
Mitochondria contain ∼1,000 different proteins, most of which are imported from the cytosol. Two import pathways that direct proteins into the mitochondrial inner membrane and matrix have been known for many years. The identification of numerous new transport components in recent proteomic studies has led to novel mechanistic insight into these pathways and the discovery of new import pathways into the outer membrane and intermembrane space. Protein translocases do not function as independent… CONTINUE READING
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