Mitochondrial processing peptidase: multiple-site recognition of precursor proteins.

@article{Ito1999MitochondrialPP,
  title={Mitochondrial processing peptidase: multiple-site recognition of precursor proteins.},
  author={Akio Ito},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={265 3},
  pages={
          611-6
        }
}
During or shortly after import of the precursor proteins into mitochondria, the amino-terminal extension peptides are first proteolytically removed by mitochondrial processing peptidase (MPP). The peptidase is a metalloendopeptidase, classified as a member of pitrilysin family, and forms a heterodimer consisting of structurally related alpha- and beta-subunits which are homologous to core proteins, core 2 and core 1, respectively, of mitochondrial ubiquinol-cytochrome c oxidoreductase complex… CONTINUE READING

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