Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease.

  title={Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease.},
  author={Joelle M van der Walt and Kristin K Nicodemus and Eden R. Martin and William K. Scott and Martha A. Nance and Ray L. Watts and Jean Pintar Hubble and Jonathan L. Haines and William C. Koller and Kelly E. Lyons and Rajesh Pahwa and Matthew B. Stern and Amy Colcher and Bradley C. Hiner and Joseph Jankovic and William G. Ondo and Fred Allen and Christopher G{\"o}tz and Gary W. Small and Francis L Mastaglia and Jeffrey M. Stajich and Adam C McLaurin and Lefkos T. Middleton and Burton L. Scott and Donald E. Schmechel and Margaret A. Pericak-Vance and Jeffery M. Vance},
  journal={American journal of human genetics},
  volume={72 4},
Mitochondrial (mt) impairment, particularly within complex I of the electron transport system, has been implicated in the pathogenesis of Parkinson disease (PD). More than half of mitochondrially encoded polypeptides form part of the reduced nicotinamide adenine dinucleotide dehydrogenase (NADH) complex I enzyme. To test the hypothesis that mtDNA variation contributes to PD expression, we genotyped 10 single-nucleotide polymorphisms (SNPs) that define the European mtDNA haplogroups in 609 white… CONTINUE READING
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