Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7β-hydroxysitosterol and 7β-hydroxycholesterol triggered apoptosis in human colon cancer cells

@article{Roussi2006MitochondrialPO,
  title={Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7β-hydroxysitosterol and 7β-hydroxycholesterol triggered apoptosis in human colon cancer cells},
  author={Stamatiki Roussi and Francine Goss{\'e} and Dalal Aoud{\'e}-Werner and Xin Zhang and Eric Marchioni and Philippe Geoffroy and Michel Miesch and Françis Raul},
  journal={Apoptosis},
  year={2006},
  volume={12},
  pages={87-96}
}
We reported previously that 7β-hydroxysitosterol and 7β-hydroxycholesterol induced apoptosis in Caco-2 cells. Apoptosis caused by 7β-hydroxysitosterol but not by 7β-hydroxycholesterol was related to a caspase-dependent process. In the present report, we compared the effects of both compounds on mitochondria integrity and on various modulators of apoptosis. When Caco-2 cells were exposed to both hydroxysterols, no changes in Bcl-2 and Bax expressions were detected indicating a Bcl-2/Bax… CONTINUE READING
Highly Cited
This paper has 47 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Dietary phytochemicals in the protection against oxysterol-induced damage.

Chemistry and physics of lipids • 2017
View 5 Excerpts
Highly Influenced

Evaluation of the cytotoxic effect of 7keto-stigmasterol and 7keto-cholesterol in human intestinal (Caco-2) cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2012
View 9 Excerpts
Highly Influenced

Lysosomal membrane permeabilization in cell death

Oncogene • 2008
View 4 Excerpts
Highly Influenced