Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7β-hydroxysitosterol and 7β-hydroxycholesterol triggered apoptosis in human colon cancer cells

@article{Roussi2006MitochondrialPO,
  title={Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7β-hydroxysitosterol and 7β-hydroxycholesterol triggered apoptosis in human colon cancer cells},
  author={Stamatiki Roussi and Francine Goss{\'e} and Dalal Aoud{\'e}-Werner and Xin Zhang and Eric Marchioni and Philippe Geoffroy and Michel Miesch and Françis Raul},
  journal={Apoptosis},
  year={2006},
  volume={12},
  pages={87-96}
}

• Stamatiki Roussi, Francine Gossé, +5 authors Françis Raul
• Published 2006 in Apoptosis
• DOI:10.1007/s10495-006-0485-y

We reported previously that 7β-hydroxysitosterol and 7β-hydroxycholesterol induced apoptosis in Caco-2 cells. Apoptosis caused by 7β-hydroxysitosterol but not by 7β-hydroxycholesterol was related to a caspase-dependent process. In the present report, we compared the effects of both compounds on mitochondria integrity and on various modulators of apoptosis. When Caco-2 cells were exposed to both hydroxysterols, no changes in Bcl-2 and Bax expressions were detected indicating a Bcl-2/Bax… CONTINUE READING

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