Mitochondrial permeability transition pore opening induces the initial process of renal calcium crystallization.

@article{Niimi2012MitochondrialPT,
  title={Mitochondrial permeability transition pore opening induces the initial process of renal calcium crystallization.},
  author={Kazuhiro Niimi and Takahiro Yasui and Masahito Hirose and Shuzo Hamamoto and Yasunori Itoh and Atsushi Okada and Yasue Kubota and Yoshiyuki Kojima and Keiichi Tozawa and Shoichi Toyota-shi Aichi-ken Sasaki and Yutaro Hayashi and Kenjiro Kohri},
  journal={Free radical biology & medicine},
  year={2012},
  volume={52 7},
  pages={
          1207-17
        }
}
  • Kazuhiro Niimi, Takahiro Yasui, +9 authors Kenjiro Kohri
  • Published in
    Free radical biology…
    2012
  • Chemistry, Medicine
  • Renal tubular cell injury induced by oxidative stress via mitochondrial collapse is thought to be the initial process of renal calcium crystallization. Mitochondrial collapse is generally caused by mitochondrial permeability transition pore (mPTP) opening, which can be blocked by cyclosporine A (CsA). Definitive evidence for the involvement of mPTP opening in the initial process of renal calcium crystallization, however, is lacking. In this study, we examined the physiological role of mPTP… CONTINUE READING

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