Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease

@inproceedings{Quintanilla2013MitochondrialPT,
  title={Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease},
  author={Rodrigo A Quintanilla and Youngnam N. Jin and R von Bernhardi and Gail V. W. Johnson},
  booktitle={Molecular Neurodegeneration},
  year={2013}
}
Mitochondrial impairment has been implicated in the pathogenesis of Huntington’s disease (HD). However, how mutant huntingtin impairs mitochondrial function and thus contributes to HD has not been fully elucidated. In this study, we used striatal cells expressing wild type (STHdhQ7/Q7) or mutant (STHdhQ111/Q111) huntingtin protein, and cortical neurons… CONTINUE READING