Mitochondrial permeability transition pore as a target for cardioprotection in the human heart.

@article{Shanmuganathan2005MitochondrialPT,
  title={Mitochondrial permeability transition pore as a target for cardioprotection in the human heart.},
  author={Selvaraj Shanmuganathan and Derek Hausenloy and Michael R Duchen and Derek M Yellon},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 1},
  pages={H237-42}
}
After an episode of myocardial ischemia, opening of the mitochondrial permeability transition pore (mPTP), at the onset of reperfusion, is a critical determinant of myocyte death. We investigated the role of the mPTP as a target for cardioprotection in the human heart. We subjected human atrial tissue, harvested from patients undergoing cardiac surgery, to a period of lethal hypoxia and investigated the effect of suppressing mPTP opening at the onset of reoxygenation. We found that suppressing… CONTINUE READING