Mitochondrial permeability transition in the crustacean Artemia franciscana: absence of a calcium-regulated pore in the face of profound calcium storage.

  title={Mitochondrial permeability transition in the crustacean Artemia franciscana: absence of a calcium-regulated pore in the face of profound calcium storage.},
  author={Michael A. Menze and Kirk R. Hutchinson and Susan M. Laborde and Steven C. Hand},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={289 1},
  • M. MenzeK. Hutchinson S. Hand
  • Published 1 July 2005
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
When mammalian mitochondria are exposed to high calcium and phosphate, a massive swelling, uncoupling of respiration, and release of cytochrome c occur. These changes are mediated by opening of the mitochondrial permeability transition pore (MPTP). Activation of the MPTP in vivo in response to hypoxic and oxidative stress leads to necrotic and apoptotic cell death. Considering that embryos of the brine shrimp Artemia franciscana tolerate anoxia for years, we investigated the MPTP in this… 

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