Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibition.

@article{Maciel2004MitochondrialPT,
  title={Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibition.},
  author={Evelise N. Maciel and Alicia J Kowaltowski and F{\'a}bio Duarte Schwalm and Juliana Moura Rodrigues and Diogo Onofre Souza and Anibal E Vercesi and Moacir Wajner and Roger F Castilho},
  journal={Journal of neurochemistry},
  year={2004},
  volume={90 5},
  pages={1025-35}
}
Changes in mitochondrial integrity, reactive oxygen species release and Ca2+ handling are proposed to be involved in the pathogenesis of many neurological disorders including methylmalonic acidaemia and Huntington's disease, which exhibit partial mitochondrial respiratory inhibition. In this report, we studied the mechanisms by which the respiratory chain complex II inhibitors malonate, methylmalonate and 3-nitropropionate affect rat brain mitochondrial function and neuronal survival. All three… CONTINUE READING

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