Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivo

@article{Haouzi2002MitochondrialPT,
  title={Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivo},
  author={Delphine Haouzi and Isabel Cohen and Helena L A Vieira and Delphine Poncet and Patricia Boya and Maria Castedo and Nathalie Vadrot and A.-S. Belzacq and Daniel Fau and Catherine Brenner and G{\'e}rard Feldmann and Guido Kroemer},
  journal={Apoptosis},
  year={2002},
  volume={7},
  pages={395-405}
}
Atractyloside (Atr) binds to the adenine nucleotide translocator (ANT) and inhibits ANT-mediated ATP/ADP exchange on the inner mitochondrial membrane. In addition, Atr can trigger opening of a non-specific ion channel, within the ANT-containing permeability transition pore complex (PTPC), which is subject to redox regulation and inhibited by cyclosporin A (CsA). Here we show that the cytotoxic effects of Atr, both in vivo and in vitro, are determined by its capacity to induce PTPC opening and… CONTINUE READING

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