Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy.

  title={Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy.},
  author={Riccardo Calvani and A Joseph and Peter J. Adhihetty and Alfredo Miccheli and Maurizio Bossola and Christiaan Leeuwenburgh and Roberto Bernabei and Emanuele Marzetti},
  journal={Biological chemistry},
  volume={394 3},
Muscle loss during aging and disuse is a highly prevalent and disabling condition, but knowledge about cellular pathways mediating muscle atrophy is still limited. Given the postmitotic nature of skeletal myocytes, the maintenance of cellular homeostasis relies on the efficiency of cellular quality control mechanisms. In this scenario, alterations in mitochondrial function are considered a major factor underlying sarcopenia and muscle atrophy. Damaged mitochondria are not only less… CONTINUE READING
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