Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration

@inproceedings{Shim2016MitochondrialPM,
  title={Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration},
  author={Myoung Sup Shim and Yuji Takihara and Keun-Young Kim and Takeshi Iwata and Beatrice Y. J. T. Yue and Masaru Inatani and Robert N. Weinreb and Guy A Perkins and W Ju},
  booktitle={Scientific reports},
  year={2016}
}
Mutations in optineurin (OPTN) are linked to the pathology of primary open angle glaucoma (POAG) and amyotrophic lateral sclerosis. Emerging evidence indicates that OPTN mutation is involved in accumulation of damaged mitochondria and defective mitophagy. Nevertheless, the role played by an OPTN E50K mutation in the pathogenic mitochondrial mechanism that underlies retinal ganglion cell (RGC) degeneration in POAG remains unknown. We show here that E50K expression induces mitochondrial fission… CONTINUE READING

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