Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

@article{Leu2004MitochondrialPA,
  title={Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex},
  author={J. Leu and P. Dumont and M. Hafey and M. Murphy and D. George},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={443-450}
}
The tumour suppressor activity of the p53 protein has been explained by its ability to induce apoptosis in response to a variety of cellular stresses. Thus, understanding the mechanism by which p53 functions in the execution of cell death pathways is of considerable importance in cancer biology. Recent studies have indicated that p53 has a direct signalling role at mitochondria in the induction of apoptosis, although the mechanisms involved are not completely understood. Here we show that… Expand
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Mitochondrial liaisons of p53.
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