Mitochondrial p32 is a critical mediator of ARF-induced apoptosis.

@article{Itahana2008MitochondrialPI,
  title={Mitochondrial p32 is a critical mediator of ARF-induced apoptosis.},
  author={Koji Itahana and Yanping Zhang},
  journal={Cancer cell},
  year={2008},
  volume={13 6},
  pages={
          542-53
        }
}
The shared exon 2 of the p14ARF-p16INK4a locus is frequently mutated in human cancers. However, in contrast to the exon 1beta-encoded N-terminal half of ARF, the function of the exon 2-encoded C-terminal half of ARF has been elusive. Here, we report that the mitochondrial protein p32/C1QBP binds the ARF C terminus. We show that p32 is required for ARF to localize to mitochondria and induce apoptosis, and that ARF mutations specifically disrupting p32 binding can impair both of these functions… CONTINUE READING
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