Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

  title={Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation},
  author={Daniel J. Fazakerley and Annabel Y. Minard and James R Krycer and Kristen C. Thomas and Jacqueline St{\"o}ckli and Dylan. J. Harney and James G. Burchfield and Ghassan J. Maghzal and Stuart Thomas Caldwell and Richard C Hartley and Roland Stocker and Michael P Murphy and David E. James},
  booktitle={The Journal of biological chemistry},
Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in insulin resistance. However, disentangling the individual roles of these processes in insulin resistance has been difficult because they often occur in tandem, and tools that selectively increase oxidant production without impairing mitochondrial respiration have been lacking. Using the dimer/monomer status of peroxiredoxin isoforms as an indicator of compartmental hydrogen peroxide burden, we provide… CONTINUE READING
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