Mitochondrial oxidative stress and dysfunction in myocardial remodelling.

  title={Mitochondrial oxidative stress and dysfunction in myocardial remodelling.},
  author={Hiroyuki Tsutsui and Shintaro Kinugawa and Shouji Matsushima},
  journal={Cardiovascular research},
  volume={81 3},
Recent experimental and clinical studies have suggested that oxidative stress is enhanced in myocardial remodelling and failure. The production of oxygen radicals is increased in the failing heart, whereas normal antioxidant enzyme activities are preserved. Mitochondrial electron transport is an enzymatic source of oxygen radical generation and can be a therapeutic target against oxidant-induced damage in the failing myocardium. Chronic increases in oxygen radical production in the mitochondria… CONTINUE READING


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