Mitochondrial oxidative phosphorylation thermodynamic efficiencies reflect physiological organ roles.

  title={Mitochondrial oxidative phosphorylation thermodynamic efficiencies reflect physiological organ roles.},
  author={Charles B. Cairns and James Walther and Alden Hood Harken and Anirban Banerjee},
  journal={The American journal of physiology},
  volume={274 5 Pt 2},
Mitochondria cannot maximize energy production, efficiency, and the cellular ATP phosphorylation potential all at the same time. The theoretical and observed determinations of coupling of oxidative phosphorylation in mitochondria from rat liver, heart, and brain were compared using classical and nonequilibrium thermodynamic measures. Additionally, the optimal thermodynamic efficiency and flow ratios were determined for control of the two energy-converting complexes of the respiratory chain… CONTINUE READING


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