Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate. A possible role in Crabtree effect induction?

@article{DazRuiz2008MitochondrialOP,
  title={Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate. A possible role in Crabtree effect induction?},
  author={Rodrigo D{\'i}az-Ruiz and Nicole Av{\'e}ret and Daniela Araiza and Beno{\^i}t Pinson and Salvador Uribe-Carvajal and Anne Devin and Michel Rigoulet},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 40},
  pages={26948-55}
}
In numerous cell types, tumoral cells, proliferating cells, bacteria, and yeast, respiration is inhibited when high concentrations of glucose are added to the culture medium. This phenomenon has been named the "Crabtree effect." We used yeast to investigate (i) the short term event(s) associated with the Crabtree effect and (ii) a putative role of hexose phosphates in the inhibition of respiration. Indeed, yeast divide into "Crabtree-positive," where the Crabtree effect occurs, and "Crabtree… CONTINUE READING
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