Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy

  title={Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy},
  author={V. I. Mayorov and Angela J. Lowrey and V Biousse and N J Newman and Susan Cline and Michael D. Brown},
  journal={BMC Biochemistry},
  pages={22 - 22}
Autosomal dominant optic atrophy (ADOA), a form of progressive bilateral blindness due to loss of retinal ganglion cells and optic nerve deterioration, arises predominantly from mutations in the nuclear gene for the mitochondrial GTPase, OPA1. OPA1 localizes to mitochondrial cristae in the inner membrane where electron transport chain complexes are enriched. While OPA1 has been characterized for its role in mitochondrial cristae structure and organelle fusion, possible effects of OPA1 on… CONTINUE READING


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