Mitochondrial oxidative phosphorylation: Debunking the concepts of electron transport chain, proton pumps, chemiosmosis and rotary ATP synthesis

@inproceedings{Manoj2017MitochondrialOP,
  title={Mitochondrial oxidative phosphorylation: Debunking the concepts of electron transport chain, proton pumps, chemiosmosis and rotary ATP synthesis},
  author={Kelath Murali Manoj},
  year={2017}
}
The prevailing half-a-century old explanation for cellular respiration solicits a synchronization of electron transfer chain (ETC) and proton pumping activity across the inner mitochondrial membrane, for generating a trans-membrane proton-electro-chemical potential. This outcome is supposedly harnessed by Complex V to synthesize ATP, working via a rotary mode. In the first part of my work (the current write-up), I highlight that a mitochondrion is a highly " proton-limited " microcosm, housing… 
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7 Citations
Background Citations
3
Results Citations
1

7 Citations

The physiological role of complex V in ATP synthesis: Murzyme functioning is viable whereas rotary conformation change model is untenable.
TLDR
The murburn paradigm succeeds the CRAS hypothesis for explaining the role of oxygen in mitochondrial physiologies of oxidative phosphorylation, thermogenesis, TMP and homeostasis.
The murburn precepts for aerobic respiration and redox homeostasis.
Consolidation of Nath's torsional mechanism of ATP synthesis and two-ion theory of energy coupling in oxidative phosphorylation and photophosphorylation.
  • S. Nath
  • Chemistry
    Biophysical chemistry
  • 2019
Coupling mechanisms in ATP synthesis: Rejoinder to "Response to molecular-level understanding of biological energy coupling and transduction".
  • S. Nath
  • Chemistry
    Biophysical chemistry
  • 2021
Chemiosmotic and murburn explanations for aerobic respiration: Predictive capabilities, structure-function correlations and chemico-physical logic.
Murburn precepts for lactic‐acidosis, Cori cycle, and Warburg effect: Interactive dynamics of dehydrogenases, protons, and oxygen
TLDR
The DROS‐based murburn theory explains the invariant active‐site structure of LDH isozymes and their multimeric nature and enrich the understanding of the underpinnings of “lactic acidosis” (lowering of physiological pH accompanied by lactate production), Warburg effect (increased lactateproduction at high pO2 by cancer cells) and approach for cancer therapy.
Murburn concept explains the acutely lethal effect of cyanide
TLDR
The μM-level IC50 and the acutely lethal effect of CN on cellular respiration could be explained by the deleterious interaction of CN ion-radical equilibrium with DROS in matrix, disrupting mitochondrial ATP synthesis.
Interaction of membrane‐embedded cytochrome b‐complexes with quinols: Classical Q‐cycle and murburn model
TLDR
It is proposed that Q‐cycle is neither necessary nor feasible at CBCs, and the classical model cannot explain the energetics, kinetics, mechanism and probabilistic considerations of bioenergetics.
Critical analysis of explanations for cellular homeostasis and electrophysiology from murburn perspective
TLDR
The new entry into the field, murburn concept, builds starting from molecular considerations to macroscopic observations, and moots "effective charge separation" and intricate "molecule-ion-radical" electron transfer equilibriums as a rationale for ionic concentration differentials and TMP variation.
Light's interaction with pigments in chloroplasts: The murburn perspective

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