Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

  title={Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells},
  author={Lei Liu and Du Feng and Guo-rong Chen and M Chen and Qiaoxia Zheng and Pingping Song and Qi Ma and Chongzhuo Zhu and R Wang and Wanjun Qi and Lei Huang and Peng Xue and B Li and Xiaohui Wang and H Jin and Jun Wang and F Yang and Pingsheng Liu and Yushan Zhu and Senfang Sui and Quan Chen},
  journal={Nature Cell Biology},
Accumulating evidence has shown that dysfunctional mitochondria can be selectively removed by mitophagy. Dysregulation of mitophagy is implicated in the development of neurodegenerative disease and metabolic disorders. How individual mitochondria are recognized for removal and how this process is regulated remain poorly understood. Here we report that FUNDC1, an integral mitochondrial outer-membrane protein, is a receptor for hypoxia-induced mitophagy. FUNDC1 interacted with LC3 through its… CONTINUE READING
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