Mitochondrial oscillations and waves in cardiac myocytes: insights from computational models.


Periodic cellwide depolarizations of mitochondrial membrane potential (PsiM) which are triggered by reactive oxygen species (ROS) and propagated by ROS-induced ROS release (RIRR) have been postulated to contribute to cardiac arrhythmogenesis and injury during ischemia/reperfusion. Two different modes of RIRR have been described: PsiM oscillations involving… (More)
DOI: 10.1016/j.bpj.2009.12.4300


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