Mitochondrial oligomers boost glycolysis in cancer stem cells to facilitate blebbishield-mediated transformation after apoptosis

@inproceedings{Jinesh2016MitochondrialOB,
  title={Mitochondrial oligomers boost glycolysis in cancer stem cells to facilitate blebbishield-mediated transformation after apoptosis},
  author={G G Jinesh and JR Molina and Li Huang and NM Laing and G. B. Mills and Menashe M Bar-Eli and A M Kamat},
  booktitle={Cell Death Discovery},
  year={2016}
}
Apoptosis culminates in secondary necrosis due to lack of ATP. Cancer stem cells form spheres after apoptosis by evoking the blebbishield emergency program. Hence, determining how blebbishields avoid secondary necrosis is crucial. Here we demonstrate that N-Myc and VEGFR2 control transformation from blebbishields, during which oligomers of K-Ras, p27, BAD, Bax, and Bak boost glycolysis to avoid secondary necrosis. Non-apoptotic cancer cells also utilize oligomers to boost glycolysis, which… CONTINUE READING
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Apoptosis: A Target for Anticancer Therapy

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