Mitochondrial nucleoids maintain genetic autonomy but allow for functional complementation

@article{Gilkerson2008MitochondrialNM,
  title={Mitochondrial nucleoids maintain genetic autonomy but allow for functional complementation},
  author={Robert W. Gilkerson and E. A. Schon and Evelyn Hernandez and Mercy M. Davidson},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={181},
  pages={1117 - 1128}
}
Mitochondrial DNA (mtDNA) is packaged into DNA-protein assemblies called nucleoids, but the mode of mtDNA propagation via the nucleoid remains controversial. Two mechanisms have been proposed: nucleoids may consistently maintain their mtDNA content faithfully, or nucleoids may exchange mtDNAs dynamically. To test these models directly, two cell lines were fused, each homoplasmic for a partially deleted mtDNA in which the deletions were nonoverlapping and each deficient in mitochondrial protein… CONTINUE READING
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The authors declare that they have no competing fi nancial interests

  • The authors declare that they have no competing…
  • 2007

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