Mitochondrial nitric oxide synthase.

@article{Ghafourifar2007MitochondrialNO,
  title={Mitochondrial nitric oxide synthase.},
  author={P. Ghafourifar and C. Sen},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2007},
  volume={12},
  pages={
          1072-8
        }
}
  • P. Ghafourifar, C. Sen
  • Published 2007
  • Biology, Medicine
  • Frontiers in bioscience : a journal and virtual library
Nitric oxide (NO) regulates several cellular functions via reversible regulation of mitochondrial respiration. Nitric oxide also reacts with mitochondrial superoxide anion to produce the potent oxidative species peroxynitrite that irreversibly hinders mitochondrial activities. Recent findings demonstrating that mitochondria produce NO via mitochondrial NO synthase (mtNOS) has intrigued several laboratories revealing crucial roles for mtNOS-derived NO and peroxynitrite in regulating the… Expand
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TLDR
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TLDR
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References

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Mitochondrial nitric oxide synthase.
TLDR
Some of the current issues regarding mtNOS, such as its isoform identity, the availability of co-factors and substrates within the organelle, and potential physiological vs. pathological roles for the enzyme are discussed within the broader context of mitochondrial regulation by NO*. Expand
Mitochondrial Nitric Oxide Synthase, Oxidative Stress and Apoptosis
TLDR
How mitochondria and cells harmonize the reversible effects of NO versus the irreversible effects of ONOO– will be discussed in this review article and the exciting recent finding of mitochondrial NO synthase will also be discussed. Expand
Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation?
In this article we demonstrate the immunocytochemical localization of nitric oxide synthase in mitochondria isolated from heart, skeletal muscle, and kidney, using a monoclonal antibody directedExpand
Mitochondrial Nitric Oxide Synthase Regulates Mitochondrial Matrix pH
TLDR
It is reported that NO, provided by an NO donor as well as bymtNOS stimulation, regulates mitochondrial matrix pH, transmembrane potential and Ca2+ buffering capacity and it is concluded that mtNOS plays a critical role in regulating mitochondrial ∆pH. Expand
Mitochondrial Production of Hydrogen Peroxide Regulation by Nitric Oxide and the Role of Ubisemiquinone
TLDR
The cellular steady‐state levels of hydrogen peroxide and the role of mitochondria in maintaining these levels are reviewed and the multisite regulation of mi1 tochondrial respiration and energy‐transducing pathways support a critical regulatory role of turbines in cell signaling pathways. Expand
Analysis of the pathways of nitric oxide utilization in mitochondria
TLDR
A survey of the major regulatory roles of nitric oxide on mitochondrial functions as an expression of two major metabolic pathways for Nitric oxide consumption: a reductive pathway, involving mitochondrial ubiquinol and yielding nitroxyl anion and an oxidative pathway involving superoxide anions and yielding peroxynitrite. Expand
Nitric oxide synthase activity in mitochondria
TLDR
The existence of a functional nitric oxide synthase (NOS) in rat liver mitochondria and its Ca2+ dependence are highly relevant for mitochondrial functioning are suggested. Expand
Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia.
TLDR
It is concluded that mtNOS is a constitutively active eNOS-like isoform and is involved in altered mitochondrial regulation during hypoxia. Expand
Biochemistry of Mitochondrial Nitric-oxide Synthase*
TLDR
The mitochondria generation of nitric oxide by mitochondria is catalyzed by a constitutive, mitochondrial nitric-oxide synthase (mtNOS), which was identified as brain NOSα by various methods and has two post-translational modifications: acylation with myristic acid and phosphorylation at the C terminus. Expand
The Regulation of Mitochondrial Oxygen Uptake by Redox Reactions Involving Nitric Oxide and Ubiquinol*
TLDR
Calculations indicate that mitochondrial ·NO decays primarily by pathways involving ONOO– formation and ubiquinol oxidation and, secondarily, by reversible binding to cytochrome oxidase. Expand
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