Mitochondrial modulators for bipolar disorder: a pathophysiologically informed paradigm for new drug development.

@article{Nierenberg2013MitochondrialMF,
  title={Mitochondrial modulators for bipolar disorder: a pathophysiologically informed paradigm for new drug development.},
  author={Andrew Nierenberg and Christine I Kansky and Brian P. Brennan and Richard Charles Shelton and Roy H. Perlis and Dan V. Iosifescu},
  journal={The Australian and New Zealand journal of psychiatry},
  year={2013},
  volume={47 1},
  pages={
          26-42
        }
}
OBJECTIVES Bipolar patients frequently relapse within 12 months of their previous mood episode, even in the context of adequate treatment, suggesting that better continuation and maintenance treatments are needed. Based on recent research of the pathophysiology of bipolar disorder, we review the evidence for mitochondrial dysregulation and selected mitochondrial modulators (MM) as potential treatments. METHODS We reviewed the literature about mitochondrial dysfunction and potential MMs worthy… CONTINUE READING
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