Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development

  title={Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development},
  author={A. Nierenberg and C. Kansky and Brian P. Brennan and R. Shelton and R. Perlis and D. Iosifescu},
  journal={Australian & New Zealand Journal of Psychiatry},
  pages={26 - 42}
  • A. Nierenberg, C. Kansky, +3 authors D. Iosifescu
  • Published 2013
  • Psychology, Medicine
  • Australian & New Zealand Journal of Psychiatry
  • Objectives: Bipolar patients frequently relapse within 12 months of their previous mood episode, even in the context of adequate treatment, suggesting that better continuation and maintenance treatments are needed. Based on recent research of the pathophysiology of bipolar disorder, we review the evidence for mitochondrial dysregulation and selected mitochondrial modulators (MM) as potential treatments. Methods: We reviewed the literature about mitochondrial dysfunction and potential MMs worthy… CONTINUE READING
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