Mitochondrial microsatellite instability in patients with metastatic colorectal cancer

@inproceedings{Venderbosch2015MitochondrialMI,
  title={Mitochondrial microsatellite instability in patients with metastatic colorectal cancer},
  author={Sabine Venderbosch and Shannon van Vliet and Moniek H C Craenmehr and Femke Simmer and Anton F. J. de Haan and C. J. A. Punt and Miriam Koopman and Iris Nagtegaal},
  booktitle={Virchows Archiv},
  year={2015}
}
Mitochondrial microsatellite instability (mtMSI), a change in length in mtDNA microsatellite sequences between normal and tumor tissue, has been described as a frequent occurrence in colorectal cancer (CRC). We evaluated the prevalence and prognostic value of mtMSI and its relation to nuclear microsatellite instability (MSI) in patients with metastatic CRC (mCRC). At six loci (D310, D514, D16184, ND1, ND5, and COX1), the mitochondrial DNA sequence was analyzed in normal and tumor tissue, and… CONTINUE READING