Mitochondrial metabolism and substrate competition in the aging Fischer rat heart.

  title={Mitochondrial metabolism and substrate competition in the aging Fischer rat heart.},
  author={Jeanie B. Mcmillin and George E. Taffet and H. Taegtmeyer and Edgar K. Hudson and Charlotte A. Tate},
  journal={Cardiovascular research},
  volume={27 12},
OBJECTIVE The objective was to examine mitochondrial oxidative metabolism of long chain fatty acids and to compare it with glucose uptake and the generation of pressure-volume work in hearts from mature and aged rats. METHODS Hearts from mature (8 to 15 months of age) and old (28 to 30 months) Fischer 344 rats were perfused as working hearts with either 10 mM glucose or glucose plus 1 mM oleic acid (2% bovine serum albumin) and rates of glucose extraction were determined. Hearts were… 

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