Mitochondrial metabolism and substrate competition in the aging Fischer rat heart.

@article{Mcmillin1993MitochondrialMA,
  title={Mitochondrial metabolism and substrate competition in the aging Fischer rat heart.},
  author={Jeanie B. Mcmillin and George E. Taffet and H. Taegtmeyer and Edgar K. Hudson and Charlotte A. Tate},
  journal={Cardiovascular research},
  year={1993},
  volume={27 12},
  pages={
          2222-8
        }
}
OBJECTIVE The objective was to examine mitochondrial oxidative metabolism of long chain fatty acids and to compare it with glucose uptake and the generation of pressure-volume work in hearts from mature and aged rats. METHODS Hearts from mature (8 to 15 months of age) and old (28 to 30 months) Fischer 344 rats were perfused as working hearts with either 10 mM glucose or glucose plus 1 mM oleic acid (2% bovine serum albumin) and rates of glucose extraction were determined. Hearts were… 

Aging skeletal muscle mitochondria in the rat: decreased uncoupling protein-3 content.

It is concluded that the in vivo observed decrease in skeletal muscle aerobic capacity with advanced age is a consequence of the decreased mitochondrial density, and it is proposed that an increased free radical production might contribute to the metabolic compromise in aging.

Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice.

Changes in myocardial substrate utilization corresponded to alterations in circulating lipids, thyroid hormone, and reductions in protein expression for peroxisome proliferator-activated receptor (PPAR)alpha and pyruvate dehydrogenase kinase (PDK)4.

Mitochondrial and Metabolic Gene Expression in the Aged Rat Heart

Aging is associated with a decline in cardiac function. Exercise intervention has been suggested as a way to improve this decrement. Age-related decline in cardiac function is associated with

Metabolic remodeling in the aging heart.

Thyroid Hormone Reverses Aging-Induced Myocardial Fatty Acid Oxidation Defects and Improves the Response to Acutely Increased Afterload

Thyroid hormone supplementation in aged mice significantly improves cardiac function potentially through restoration of fatty acid oxidation, and shows diminished ability to increase cardiac work due to substrate limitations.

Ageing-induced decrease in cardiac mitochondrial function in healthy rats.

The results show an important decline for all bioenergetic parameters for both complex I and complex II supported-respiration, a decreased Δψ in mitochondria energized with complex I substrates, and an increased mitochondrial ROS production in the old compared with the adult group.

Impact of aging on substrate metabolism by the human heart.

...