Mitochondrial metabolism and substrate competition in the aging Fischer rat heart.

  title={Mitochondrial metabolism and substrate competition in the aging Fischer rat heart.},
  author={Jeanie B. Mcmillin and George E. Taffet and H. Taegtmeyer and Edgar K. Hudson and Charlotte A. Tate},
  journal={Cardiovascular research},
  volume={27 12},
OBJECTIVE The objective was to examine mitochondrial oxidative metabolism of long chain fatty acids and to compare it with glucose uptake and the generation of pressure-volume work in hearts from mature and aged rats. METHODS Hearts from mature (8 to 15 months of age) and old (28 to 30 months) Fischer 344 rats were perfused as working hearts with either 10 mM glucose or glucose plus 1 mM oleic acid (2% bovine serum albumin) and rates of glucose extraction were determined. Hearts were… 

Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice.

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Mitochondrial and Metabolic Gene Expression in the Aged Rat Heart

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Metabolic remodeling in the aging heart.

Ageing-induced decrease in cardiac mitochondrial function in healthy rats.

The results show an important decline for all bioenergetic parameters for both complex I and complex II supported-respiration, a decreased Δψ in mitochondria energized with complex I substrates, and an increased mitochondrial ROS production in the old compared with the adult group.

Impact of aging on substrate metabolism by the human heart.

Cardiac Metabolism and Energetic Control

Typical metabolic features of the healthyheart, the foetal heart, the hypertrophied or failing heart,The aged heart and the obese or diabetic heart are summarized.