Mitochondrial membrane permeabilization in neuronal injury

  title={Mitochondrial membrane permeabilization in neuronal injury},
  author={Lorenzo Galluzzi and Klas Blomgren and Guido Kroemer},
  journal={Nature Reviews Neuroscience},
Acute neurological conditions such as cerebrovascular diseases and trauma are associated with irreversible loss of neurons and glial cells. Severe or prolonged injury results in uncontrollable cell death within the core of lesions. Conversely, cells that are less severely damaged succumb in a relatively slow fashion, frequently via the intrinsic pathway of cell death, through the deterioration of mitochondrial functions. The permeabilization of mitochondrial membranes determines whether cells… CONTINUE READING
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