Mitochondrial membrane permeabilization: the sine qua non for cell death.

  title={Mitochondrial membrane permeabilization: the sine qua non for cell death.},
  author={Jeffrey Armstrong},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={28 3},
Mitochondria are essential for maintaining cell life but they also play a role in regulating cell death, which occurs when their membranes become permeabilized. Mitochondria possess two distinct membrane systems including an outer membrane in close communication with the cytosol and an inner membrane involved in energy transduction. Outer membrane permeabilization is regulated by Bcl-2 family proteins, which control the release of proteins from the mitochondrial intermembrane space; these… CONTINUE READING
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