Mitochondrial medicine--recent advances.

@article{Graff1999MitochondrialMA,
  title={Mitochondrial medicine--recent advances.},
  author={Caroline Graff and D. A. Clayton and N-G. Larsson},
  journal={Journal of internal medicine},
  year={1999},
  volume={246 1},
  pages={11-23}
}
Mitochondria contain the respiratory chain enzyme complexes that carry out oxidative phosphorylation and produce the main part of cellular energy in the form of ATP. Mitochondrial DNA (mtDNA) encodes essential subunits of the respiratory chain and is thus critical for maintaining cellular energy production. The first pathogenic mtDNA mutations were reported in 1988, and today more than 50 disease-causing mtDNA mutations have been identified. In addition, mtDNA mutations have been implicated in… CONTINUE READING
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