Mitochondrial medicine: neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent.

@article{Poeggeler2005MitochondrialMN,
  title={Mitochondrial medicine: neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent.},
  author={Burkhard Poeggeler and Gr{\'e}gory Durand and Ange Polidori and Miguel A. Pappolla and Ignacio Vega-Naredo and Ana M Coto-Montes and Jutta B{\"o}ker and R{\"u}diger Hardeland and Bernard Pucci},
  journal={Journal of neurochemistry},
  year={2005},
  volume={95 4},
  pages={962-73}
}
The search for effective treatments that prevent oxidative stress associated with premature ageing and neurodegenerative diseases is an important area of neurochemical research. As age- and disease-related oxidative stress is frequently associated with mitochondrial dysfunction, amphiphilic antioxidant agents of high stability and selectivity that target these organelles can provide on-site protection. Such an amphiphilic nitrone protected human neuroblastoma cells at low micromolar… CONTINUE READING
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