Mitochondrial mechanisms of neural cell apoptosis.

  title={Mitochondrial mechanisms of neural cell apoptosis.},
  author={Brian M Polster and Gary Fiskum},
  journal={Journal of neurochemistry},
  volume={90 6},
The importance of calcium overload, mitochondrial dysfunction, and free radical generation to neuropathological processes has been recognized for many years. Only more recently has evidence accumulated that the programmed cell death process of apoptosis plays an integral role not only in the development of the nervous system, but in the loss of cells following acute neurological insults and chronic disease. In 1996 came the landmark discovery that cytochrome c, an evolutionary old and essential… CONTINUE READING