Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise.

@article{Holloway2006MitochondrialLC,
  title={Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise.},
  author={Graham P Holloway and V{\'e}ronic B{\'e}zaire and George J. F. Heigenhauser and Narendra N. Tandon and Jan F. C. Glatz and Joost J. F. P. Luiken and Arend Bonen and Lawrence Leon Spriet},
  journal={The Journal of physiology},
  year={2006},
  volume={571 Pt 1},
  pages={201-10}
}
Mitochondrial fatty acid transport is a rate-limiting step in long chain fatty acid (LCFA) oxidation. In rat skeletal muscle, the transport of LCFA at the level of mitochondria is regulated by carnitine palmitoyltransferase I (CPTI) activity and the content of malonyl-CoA (M-CoA); however, this relationship is not consistently observed in humans. Recently, fatty acid translocase (FAT)/CD36 was identified on mitochondria isolated from rat and human skeletal muscle and found to be involved in… CONTINUE READING