Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K

@article{Lomonosova2005MitochondrialLO,
  title={Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K},
  author={Elena Lomonosova and Thirugnana Subramanian and G. Chinnadurai},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={6796-6808}
}
Recent results have revealed that the p53 tumor suppressor protein possesses a direct transcription-independent apoptotic activity. During apoptosis induced by genotoxic stress, a small fraction of p53 is targeted to mitochondria where it initiates apoptosis by causing mitochondrial dysfunction. In adenovirus-infected cells, the expression of E1A protein… CONTINUE READING