Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance.

@article{Liou2005MitochondrialLO,
  title={Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance.},
  author={J. Y. Liou and Nena Aleksic and Shu-fen Chen and Tsai-Jung Han and Song-Kun Shyue and Kenneth K. Wu},
  journal={Experimental cell research},
  year={2005},
  volume={306 1},
  pages={75-84}
}
Cyclooxygenase-2 (COX-2) is inducible by myriad stimuli. The inducible COX-2 in primary cultured human cells has been reported to localize to nuclear envelope, endoplasmic reticulum, nucleus and caveolae. As COX-2 plays an important role in tumor growth, we were interested in its subcellular location in cancer cells. We examined COX-2 localization in several cancer cell lines by confocal microscopy. A majority of COX-2 was colocalized with heat shock protein 60, a mitochondrial protein, in… CONTINUE READING

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