Mitochondrial involvement in amyotrophic lateral sclerosis

Abstract

Despite numerous reports demonstrating mitochondrial abnormalities associated with amyotrophic lateral sclerosis (ALS), the role of mitochondrial dysfunction in the disease onset and progression remains unknown. The intrinsic mitochondrial apoptotic program is activated in the central nervous system of mouse models of ALS harboring mutant superoxide… (More)
DOI: 10.1385/MN:33:2:113

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