Mitochondrial introns aI1 and/or aI2 are needed for the in vivo deletion of intervening sequences

  title={Mitochondrial introns aI1 and/or aI2 are needed for the in vivo deletion of intervening sequences},
  author={Estelle Levra-Juillet and Annick Boulet and Bertrand S{\'e}raphin and Michel Simon and G{\'e}rard Faye},
  journal={Molecular and General Genetics MGG},
Some pet- (or mit-) mutations impeding the splicing of one or several intron(s) of the yeast mitochondrial pre-mRNA(s) are suppressed in vivo by the DNA deletion of these introns. We have genetically demonstrated that introns aI1 and/or aI2 of the cytochrome c oxidase subunit 1 gene are necessary for this deletion process. The facts that adjacent introns are simultaneously deleted and that, in the pet- (or mit-) mutants which easily revert by intron deletion, the splicing of the introns they… CONTINUE READING

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