Mitochondrial injury underlies hyporeactivity of arterial smooth muscle in severe shock.

Abstract

BACKGROUND Our previous data showed membrane hyperpolarization of arteriolar smooth muscle cells (ASMCs) caused by adenosine triphosphate (ATP)-sensitive potassium channels (K(ATP)) activation contributed to vascular hyporeactivity in shock. Despite supply of oxygen and nutrients, vascular hyporeactivity to vasoconstrictor agents still remains, which may… (More)
DOI: 10.1038/ajh.2010.184

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