Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.

@article{Nargund2012MitochondrialIE,
  title={Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.},
  author={Amrita Mohan Nargund and Mark W. Pellegrino and Christopher J. Fiorese and Brooke M. Baker and Cole M. Haynes},
  journal={Science},
  year={2012},
  volume={337 6094},
  pages={587-90}
}
To better understand the response to mitochondrial dysfunction, we examined the mechanism by which ATFS-1 (activating transcription factor associated with stress-1) senses mitochondrial stress and communicates with the nucleus during the mitochondrial unfolded protein response (UPR(mt)) in Caenorhabditis elegans. We found that the key point of regulation is the mitochondrial import efficiency of ATFS-1. In addition to a nuclear localization sequence, ATFS-1 has an N-terminal mitochondrial… CONTINUE READING
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