Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons.

@article{Ohno2014MitochondrialIM,
  title={Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons.},
  author={Nobuhiko Ohno and Hao Chiang and Don Mahad and Grahame J Kidd and Liping Liu and Richard M Ransohoff and Zu-Hang Sheng and Hitoshi Komuro and Bruce D Trapp},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 27},
  pages={9953-8}
}
Axonal degeneration is a primary cause of permanent neurological disability in individuals with the CNS demyelinating disease multiple sclerosis. Dysfunction of axonal mitochondria and imbalanced energy demand and supply are implicated in degeneration of chronically demyelinated axons. The purpose of this study was to define the roles of mitochondrial volume and distribution in axonal degeneration following acute CNS demyelination. We show that the axonal mitochondrial volume increase following… CONTINUE READING
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