Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus.

@article{Gergely2002MitochondrialHA,
  title={Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus.},
  author={P{\'e}ter Attila Gergely and Craig Grossman and Brian P Niland and Ferenc Puskas and Hom Neupane and Fatme Allam and Katalin B{\'a}nki and Paul E. Phillips and Andr{\'a}s Perl},
  journal={Arthritis and rheumatism},
  year={2002},
  volume={46 1},
  pages={175-90}
}
OBJECTIVE Peripheral blood lymphocytes (PBLs) from systemic lupus erythematosus (SLE) patients exhibit increased spontaneous and diminished activation-induced apoptosis. We tested the hypothesis that key biochemical checkpoints, the mitochondrial transmembrane potential (deltapsim) and production of reactive oxygen intermediates (ROIs), mediate the imbalance of apoptosis in SLE. METHODS We assessed the deltapsim with potentiometric dyes, measured ROI production with oxidation-sensitive… CONTINUE READING

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