Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA

@article{Herrmann1994MitochondrialHS,
  title={Mitochondrial heat shock protein 70, a molecular chaperone for
 proteins encoded by mitochondrial DNA},
  author={Johannes M Herrmann and Rosemary A. Stuart and Elizabeth A Craig and Walter Neupert},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={127},
  pages={893 - 902}
}
Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix. Here, we describe a role for mt-Hsp70 in chaperoning proteins encoded by mitochondrial DNA and synthesized within mitochondria. The availability of mt-Hsp70 function influences the pattern of proteins synthesized in mitochondria of yeast both in vivo and in vitro. In particular, we show that… CONTINUE READING