Mitochondrial glutathione uptake: characterization in isolated brain mitochondria and astrocytes in culture.

@article{Wadey2009MitochondrialGU,
  title={Mitochondrial glutathione uptake: characterization in isolated brain mitochondria and astrocytes in culture.},
  author={Alison L Wadey and H{\aa}kan Muyderman and Perrin T Kwek and Neil Sims},
  journal={Journal of neurochemistry},
  year={2009},
  volume={109 Suppl 1},
  pages={101-8}
}
Glutathione in the mitochondria is an important determinant of cellular responses to oxidative stress. Mitochondrial glutathione is maintained by uptake from the cytosol, a process that has been little studied in brain cells. In the present study, measurements using isolated rat brain mitochondria showed a rapid uptake of [3H]-glutathione that was strongly… CONTINUE READING